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Congenital CMV Treatment — RACP Paediatrics MCQ

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HardInfectious DiseaseCongenital CMV TreatmentRACP Paediatrics

A newborn presents with microcephaly, periventricular calcifications, sensorineural hearing loss, and hepatosplenomegaly. His mother had a flu-like illness during early pregnancy. Urine CMV PCR is positive. What is the recommended treatment?

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Correct answer: D — Oral valganciclovir for 6 months

Symptomatic congenital CMV (CNS involvement, hearing loss) should be treated with oral valganciclovir for 6 months. This improves hearing and developmental outcomes. Treatment should be commenced within the first month of life for best outcomes.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Congenital CMV