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DMD Corticosteroid Timing — RACP Paediatrics MCQ

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ModerateNeurology & DevelopmentDMD Corticosteroid TimingRACP Paediatrics

A 2-year-old boy presents with progressive weakness and loss of motor milestones. His CK is 15,000 U/L. He has pseudohypertrophy of the calves and a positive Gowers sign. Genetic testing confirms a deletion in the dystrophin gene. At what age should corticosteroid treatment be commenced?

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Correct answer: C — When the child starts to lose motor skills (typically 4-5 years)

DMD: corticosteroids (prednisolone or deflazacort) should be commenced when motor function plateaus or begins to decline, typically around 4-5 years of age. They prolong ambulation by 2-3 years and improve respiratory and cardiac function. Multidisciplinary care is essential.

Reference: RACP – 2024 – Paediatric Curriculum: Neuromuscular Disorders