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Paracetamol for PDA Closure — RACP Paediatrics MCQ

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ModerateCardiologyParacetamol for PDA ClosureRACP Paediatrics

A premature infant at 26 weeks has a significant PDA. What pharmacological agent is increasingly used as an alternative to ibuprofen for PDA closure?

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Correct answer: C — Paracetamol (acetaminophen)

IV or oral paracetamol has emerged as an effective alternative to NSAIDs (ibuprofen, indomethacin) for PDA closure in preterm infants, with potentially fewer renal and GI side effects. Multiple RCTs have shown comparable efficacy.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Patent Ductus Arteriosus