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Biologic Therapy in Asthma — RACP Paediatrics MCQ

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HardRespiratoryBiologic Therapy in AsthmaRACP Paediatrics

A 15-year-old girl with poorly controlled asthma is commenced on omalizumab (anti-IgE monoclonal antibody). What is the primary indication for biologic therapy in paediatric asthma?

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Correct answer: A — Severe allergic asthma uncontrolled despite high-dose ICS/LABA with optimised modifiable factors

Biologic therapies (omalizumab for allergic asthma, mepolizumab/dupilumab for eosinophilic asthma) are indicated for severe asthma uncontrolled on step 4/5 therapy after confirming adherence, technique, and managing comorbidities.

Reference: National Asthma Council Australia – 2024 – Australian Asthma Handbook