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Splenic Sequestration in SCD — RACP Paediatrics MCQ

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HardHaematology & OncologySplenic Sequestration in SCDRACP Paediatrics

A 10-year-old boy with sickle cell disease presents with sudden onset of pallor, tachycardia, and rapidly enlarging spleen. Hb has dropped from 80 to 35 g/L. What is the diagnosis?

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Correct answer: D — Acute splenic sequestration crisis

Acute splenic sequestration: rapid pooling of blood in the spleen causing sudden severe anaemia and hypovolaemia. Requires urgent transfusion and fluid resuscitation.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Sickle Cell Disease