Infantile Spasms — RACP Paediatrics MCQ

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HardNeurology & DevelopmentInfantile SpasmsRACP Paediatrics

A 3-year-old presents with infantile spasms (clusters of flexion spasms on waking). EEG shows hypsarrhythmia. After excluding tuberous sclerosis, what is the first-line treatment?

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Correct answer: D — Prednisolone (or ACTH)

For infantile spasms without TSC, high-dose prednisolone or ACTH is first-line. Vigabatrin is first-line only in TSC-associated spasms.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Infantile Spasms