Drug Hypersensitivity in Epilepsy — RACP Paediatrics MCQ

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HardNeurology & DevelopmentDrug Hypersensitivity in EpilepsyRACP Paediatrics

A 14-year-old on carbamazepine develops SJS. Which alternative anti-seizure medication should be avoided due to cross-reactivity?

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Correct answer: C — Lamotrigine

Lamotrigine has significant cross-reactivity with carbamazepine for SJS/TEN as both are aromatic ASMs.

Reference: AMH Children's Dosing Companion – 2024 – Anti-Seizure Medications