Lennox-Gastaut Syndrome — RACP Paediatrics MCQ

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HardNeurology & DevelopmentLennox-Gastaut SyndromeRACP Paediatrics

A 6-year-old has sudden head drops and falls. EEG shows generalised slow spike-and-wave <2.5 Hz. Also has tonic seizures in sleep. First-line anti-seizure medication?

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Correct answer: A — Sodium valproate

Lennox-Gastaut syndrome: sodium valproate is first-line. Carbamazepine may worsen atonic and absence seizures.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Epileptic Encephalopathies