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Acute Liver Failure — RACP Paediatrics MCQ

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HardGastroenterologyAcute Liver FailureRACP Paediatrics

A 3-year-old presents with acute liver failure following a febrile illness. Encephalopathy, INR 6.5, hypoglycaemia. Paracetamol undetectable. Hepatitis serology negative. Most important investigation?

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Correct answer: B — Metabolic screen (amino acids, organic acids, acylcarnitine profile)

Acute liver failure without identifiable toxic or viral cause requires urgent metabolic investigation to identify treatable conditions.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Acute Liver Failure