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Erythema Multiforme — RACP Paediatrics MCQ

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ModerateDermatologyErythema MultiformeRACP Paediatrics

A 10-year-old presents with a target (iris) lesion rash on the extremities after a recent cold sore. There are no mucosal lesions. What is the most likely diagnosis?

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Correct answer: D — Erythema multiforme minor

Erythema multiforme (EM) minor is characterised by target (iris) lesions, typically on the extremities and acral surfaces, often precipitated by herpes simplex virus (HSV) infection. EM minor involves skin only, without mucosal involvement. EM major involves mucous membranes. Stevens-Johnson syndrome is a distinct entity, usually drug-induced, with widespread mucocutaneous involvement.

Reference: Therapeutic Guidelines – 2024 – Dermatology: Erythema Multiforme