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Growth Hormone Deficiency — RACP Paediatrics MCQ

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ModerateEndocrinologyGrowth Hormone DeficiencyRACP Paediatrics

A 3-year-old girl presents with short stature (height <3rd centile, mid-parental height 50th centile), low growth velocity, and delayed bone age. IGF-1 is low. Growth hormone stimulation testing shows a peak GH of 3 mcg/L (normal >10). What is the treatment?

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Correct answer: B — Recombinant growth hormone therapy

Growth hormone deficiency confirmed by peak GH <10 mcg/L on two stimulation tests, with low IGF-1, reduced growth velocity, and delayed bone age, is an indication for recombinant growth hormone (rhGH) therapy. Treatment is given as daily subcutaneous injections and should be initiated early for optimal final height outcome. Other causes of short stature (hypothyroidism, coeliac disease, Turner syndrome) should be excluded.

Reference: RACP – 2024 – Paediatric Curriculum: Growth and Endocrinology