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Central Precocious Puberty — RACP Paediatrics MCQ

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ModerateEndocrinologyCentral Precocious PubertyRACP Paediatrics

A 6-year-old girl presents with breast development (Tanner stage 3), pubic hair (Tanner stage 2), and a growth velocity of 10 cm/year. Bone age is 9 years. LH is elevated at 5 IU/L (pubertal range) on GnRH stimulation test. What is the most likely diagnosis?

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Correct answer: B — Central precocious puberty

Central precocious puberty (CPP) is defined as puberty onset before age 8 in girls, with progressive development, advanced bone age, and elevated basal or GnRH-stimulated LH (>5 IU/L indicates pubertal activation of the HPG axis). CPP is treated with GnRH agonists (e.g. leuprorelin) to suppress the HPG axis. MRI brain is indicated to exclude intracranial pathology.

Reference: RCH Melbourne – 2024 – Clinical Practice Guidelines: Precocious Puberty