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Helicobacter pylori Infection — RACP Paediatrics MCQ

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ModerateGastroenterologyHelicobacter pylori InfectionRACP Paediatrics

A 15-year-old boy presents with epigastric pain worse after eating, nausea, and weight loss. He was born in Afghanistan and arrived in Australia 6 months ago. Upper endoscopy shows antral nodularity with a duodenal ulcer. CLO test is positive. What is the most appropriate first-line treatment?

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Correct answer: E — Triple therapy: PPI + amoxicillin + clarithromycin for 14 days

A positive CLO test confirms Helicobacter pylori infection. First-line eradication therapy in children is triple therapy with a PPI, amoxicillin, and clarithromycin for 14 days. Antimicrobial susceptibility testing should be performed where available. Treatment duration of 14 days has higher eradication rates than 7-day courses.

Reference: AUSPGHAN – 2024 – Position Statement on Helicobacter pylori Infection in Children