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RSV Prophylaxis — RACP Paediatrics MCQ

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HardRespiratoryRSV ProphylaxisRACP Paediatrics

A 10-month-old infant born at 26 weeks gestation is being discharged from the neonatal unit for the first time in April. He has chronic neonatal lung disease. His parents ask about RSV prevention. According to Australian guidelines, what is the most appropriate recommendation?

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Correct answer: C — Nirsevimab single dose

Nirsevimab is a long-acting monoclonal antibody given as a single dose for RSV prevention. It has been approved in Australia for infants in their first RSV season, including those at high risk due to prematurity and chronic lung disease. It is replacing palivizumab (which required monthly dosing) in many centres. The Australian NIP now includes maternal RSV vaccination in pregnancy, but for infants already born, nirsevimab is recommended.

Reference: Australian Immunisation Handbook – 2025 – RSV Prevention