skip to main content

Cystic Fibrosis — RACP Paediatrics MCQ

Instant feedback + full explanation. One question, done properly.

HardRespiratoryCystic FibrosisRACP Paediatrics

A 12-year-old boy with cystic fibrosis (CF) has chronic Pseudomonas aeruginosa colonisation. His latest spirometry shows FEV1 of 65% predicted, down from 78% six months ago. What is the most appropriate additional therapy to consider?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Inhaled tobramycin on a month-on/month-off cycle

For chronic Pseudomonas infection in CF with declining lung function, inhaled anti-pseudomonal antibiotics (e.g. tobramycin 300 mg nebulised BD, month-on/month-off) are recommended to reduce bacterial load and slow decline. Azithromycin is used as an anti-inflammatory but does not directly target Pseudomonas colonisation. IV antibiotics are reserved for acute exacerbations.

Reference: Australian Cystic Fibrosis Guidelines – 2024 – Management of Cystic Fibrosis in Australia