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UC CRC Surveillance — RACP Adult Medicine MCQ

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HardGastroenterologyUC CRC SurveillanceRACP Adult Medicine

A 48-year-old BRCA2 carrier has one first-degree relative with pancreatic adenocarcinoma. She asks about pancreatic surveillance. Which advice best reflects current Australian risk management?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: AConsider annual MRI/MRCP or endoscopic ultrasound in an expert trial program

Explanation lettering: D = shown as A · E = shown as B · B = shown as C · A = shown as D · C = shown as E

D is correct. Evidence remains emerging; eviQ supports considering annual MRI/MRCP or EUS from around 50 in BRCA carriers with an affected close relative, preferably within an expert research program. A and B are unproven. C morbidity precludes prophylactic pancreatectomy. E ignores the established pancreatic-risk association.

Reference: eviQ, BRCA1 or BRCA2 risk management (female): https://www.eviq.org.au/cancer-genetics/adult/risk-management/3814-brca1-or-brca2-risk-management-female