Hypomagnesaemia QT Prolongation — RACP Adult Medicine MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: C — Hypomagnesaemia
Hypomagnesaemia causes QT prolongation by reducing the repolarisation reserve of cardiac myocytes. Furosemide (loop diuretic) causes renal magnesium wasting. Spironolactone partially offsets potassium loss but does not prevent magnesium depletion. Treatment: IV magnesium sulfate (10-20 mmol) then oral magnesium supplementation. Check and correct Mg²⁺ before attributing QT prolongation to drugs. Hypomagnesaemia also potentiates drug-induced QT prolongation and is a risk factor for torsades de pointes.
Reference: AMH – 2025; eTG Cardiovascular 2024; CredibleMeds