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Alzheimer Disease — RACP Adult Medicine MCQ

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HardNeurologyAlzheimer DiseaseRACP Adult Medicine

A 72-year-old with biomarker-supported Alzheimer disease has mild dementia, preserved mobility and no major conduction disease. Which symptomatic pharmacological treatment is reasonable?

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Correct answer: BOffer a cholinesterase inhibitor with monitoring of cognition, function, pulse, weight and adverse effects

The best answer is “Offer a cholinesterase inhibitor with monitoring of cognition, function, pulse, weight and adverse effects”. Donepezil, rivastigmine or galantamine can provide modest symptomatic benefit in mild-to-moderate Alzheimer disease. Review includes bradycardia, syncope, gastrointestinal effects, weight and whether function benefits. Care also requires advance planning, driving and medication-safety review, carer support and vascular-risk management; antipsychotics and sedatives can worsen harm.

Reference: Dementia Australia: Clinical resources for health professionals: https://www.dementia.org.au/professionals