skip to main content

Leser-Trélat Sign — RACP Adult Medicine MCQ

Instant feedback + full explanation. One question, done properly.

ModerateGastroenterologyLeser-Trélat SignRACP Adult Medicine

A 60-year-old man presents with sudden onset of multiple seborrhoeic keratoses over 3 months (Leser-Trélat sign). He has weight loss and epigastric pain. OGD shows a gastric adenocarcinoma. What is the most likely paraneoplastic skin sign?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: B — Leser-Trélat sign

Sudden eruptive seborrhoeic keratoses (Leser-Trélat sign) associated with internal malignancy — most commonly gastric adenocarcinoma and lymphoma. While individual SKs are benign, their rapid onset should prompt malignancy screening. Other paraneoplastic skin signs: acanthosis nigricans (gastric cancer), erythema gyratum repens (lung cancer), Bazex syndrome/acrokeratosis paraneoplastica (SCC head/neck).

Reference: eTG Dermatology – 2024; Curth 1976 Paraneoplastic Criteria