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Severe CAP ICU — RACP Adult Medicine MCQ

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EasyRespiratorySevere CAP ICURACP Adult Medicine

A 70-year-old man with COPD presents with severe CAP. He is confused, urea 12 mmol/L, RR 34, BP 80/50, SpO₂ 86% on 2L O₂. CURB-65 is 5. He requires intubation for respiratory failure. Lactate is 5.5 mmol/L. Sputum Gram stain shows gram-positive diplococci. What is the most appropriate antibiotic regimen?

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Correct answer: BICU admission

CURB-65 ≥4 with septic shock and respiratory failure requiring intubation is severe CAP requiring ICU admission. Empirical IV antibiotics for severe CAP per eTG 2025: ceftriaxone 1 g IV daily PLUS azithromycin 500 mg IV daily (or doxycycline). The combination covers typical (S. pneumoniae, H. influenzae) and atypical (Legionella, Mycoplasma) pathogens. De-escalate based on culture and sensitivity.

Reference: eTG Antibiotic – 2025 – Severe CAP; Surviving Sepsis 2021