SLEDAI Scoring — RACP Adult Medicine MCQ

Instant feedback + full explanation. One question, done properly.

HardRheumatologySLEDAI ScoringRACP Adult Medicine

A 28-year-old woman with SLE presents with fatigue and arthralgia. Her SLEDAI score is calculated to guide treatment decisions. Which component of the SLEDAI carries the highest point weighting?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: D — Seizure

The SLEDAI-2K (Systemic Lupus Erythematosus Disease Activity Index) assigns the highest point values to severe organ-threatening manifestations: seizure (8 points), psychosis (8 points), organic brain syndrome (8 points), visual disturbance (8 points), and cerebrovascular disease (8 points). Renal activity (proteinuria, haematuria, casts, pyuria) scores 4 points each. Arthritis scores 4 points. SLEDAI guides treatment escalation and trial endpoints.

Reference: Bombardier 1992 SLEDAI; EULAR 2024 SLE