Malaria Prophylaxis PNG — RACP Adult Medicine MCQ

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EasyInfectious DiseasesMalaria Prophylaxis PNGRACP Adult Medicine

A 30-year-old woman is travelling to Papua New Guinea for 3 weeks. She has no medical history and is not pregnant. She asks about malaria prophylaxis. The region has chloroquine-resistant P. falciparum malaria. What is the most appropriate malaria prophylaxis?

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Correct answer: D — Atovaquone-proguanil (Malarone)

Papua New Guinea has chloroquine-resistant P. falciparum. Recommended prophylaxis options (eTG 2025): atovaquone-proguanil (1 tab daily, start 1-2 days before, continue 7 days after), doxycycline (100 mg daily, start 1-2 days before, continue 4 weeks after), or mefloquine (weekly, start 2-3 weeks before, continue 4 weeks after). Atovaquone-proguanil has the most convenient dosing schedule and fewest neuropsychiatric side effects.

Reference: eTG Antibiotic – 2025 – Malaria Prophylaxis; WHO 2024