skip to main content

Hypokalaemia with Hypomagnesaemia — RACP Adult Medicine MCQ

Instant feedback + full explanation. One question, done properly.

ModerateNephrologyHypokalaemia with HypomagnesaemiaRACP Adult Medicine

A 55-year-old man on furosemide presents with muscle weakness and cramps. K⁺ is 2.5 mmol/L. Mg²⁺ is 0.5 mmol/L. ECG shows prominent U waves and flattened T waves. He is haemodynamically stable with no arrhythmias. What is the most appropriate replacement strategy?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: DIV magnesium sulfate 10 mmol over 1 hour then oral Mg replacement, PLUS IV/oral KCl

Hypokalaemia with concurrent hypomagnesaemia requires magnesium correction FIRST — potassium repletion is ineffective until magnesium is repleted. Magnesium deficiency causes renal potassium wasting via ROMK channels. Give IV MgSO₄ (10-20 mmol over 1-2 hours) followed by oral Mg, PLUS KCl replacement (oral or IV at max 20 mmol/hr peripherally, 40 mmol/hr centrally).

Reference: eTG – 2024 – Electrolyte Replacement; KDIGO 2024