HBV Vaccination Immunity — RACP Adult Medicine MCQ
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Correct answer: D — Immunity from vaccination
HBsAg negative + anti-HBs positive (>10 mIU/mL) + anti-HBc negative = immunity from vaccination. Anti-HBc is the key differentiator: negative anti-HBc means no prior infection (only vaccination produces isolated anti-HBs without anti-HBc). Anti-HBs >100 mIU/mL indicates robust vaccine response. No further doses needed.
Reference: GESA – 2022 – Hepatitis B; Australian Immunisation Handbook 2024