Cyanide Poisoning in Fire — RACP Adult Medicine MCQ
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Correct answer: E — Cyanide poisoning
House fire with altered consciousness, elevated COHb, AND unexplained lactic acidosis despite 100% O₂ suggests concurrent cyanide poisoning (from combustion of synthetic materials). Cyanide inhibits cytochrome c oxidase, causing cellular hypoxia with elevated lactate. Treatment: IV hydroxocobalamin (Cyanokit, 5 g over 15 minutes). Sodium thiosulfate is an alternative.
Reference: Toxicology Handbook (Murray) 3rd Ed; eTG Emergency 2024