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Vaccination in Immunosuppression — RACP Adult Medicine MCQ

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EasyInfectious DiseasesVaccination in ImmunosuppressionRACP Adult Medicine

A 25-year-old woman with SLE on mycophenolate and prednisolone 10 mg daily asks about influenza vaccination. She has never had an adverse reaction to vaccines. What is the most appropriate vaccination advice?

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Correct answer: E — Inactivated influenza vaccine annually

Inactivated influenza vaccine is safe and recommended annually for immunosuppressed patients. Live vaccines (including live attenuated influenza vaccine) are contraindicated in patients on immunosuppressive therapy (mycophenolate, prednisolone >20 mg/day equivalent). Immune response may be attenuated but still provides partial protection. Vaccination should ideally occur when immunosuppression is minimal.

Reference: ATAGI – 2024 – Australian Immunisation Handbook; ASCIA 2024