Maculopapular Drug Eruption — RACP Adult Medicine MCQ

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EasyRheumatologyMaculopapular Drug EruptionRACP Adult Medicine

A 60-year-old man develops a widespread erythematous maculopapular rash on day 10 of amoxicillin therapy. He is afebrile with no mucosal involvement, no organ dysfunction, and eosinophil count is normal. What is the most likely drug rash?

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Correct answer: A — Simple maculopapular drug eruption

A non-severe maculopapular rash appearing 7–14 days after drug initiation without fever, mucosal involvement, organ dysfunction, or eosinophilia is a simple exanthematous (maculopapular) drug eruption. It is the most common cutaneous drug reaction. Management is drug cessation and symptomatic treatment (topical corticosteroids, antihistamines). Rash resolves within 1–2 weeks.

Reference: eTG Dermatology – 2024 – Drug Rashes