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Drug-Induced Pancreatitis — RACP Adult Medicine MCQ

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ModerateGastroenterologyDrug-Induced PancreatitisRACP Adult Medicine

A 52-year-old woman with SLE on azathioprine presents with acute pancreatitis (lipase 3× ULN). She has no gallstones and no alcohol use. She was started on azathioprine 6 weeks ago. What is the most likely cause?

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Correct answer: B — Drug-induced pancreatitis

Azathioprine is a well-recognised cause of drug-induced pancreatitis (occurs in 3–5% of patients, typically within weeks to months of initiation). Other common drug causes include sodium valproate, mesalazine, thiazides, and GLP-1 agonists. The drug must be ceased and not re-challenged. The pancreatitis is usually mild and self-limiting.

Reference: AMH – 2025 – Drug-Induced Pancreatitis; GESA 2024