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DVT in Pregnancy — RACP Adult Medicine MCQ

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ModerateHaematologyDVT in PregnancyRACP Adult Medicine

A 30-year-old woman at 28 weeks gestation presents with left leg swelling and a confirmed proximal DVT on ultrasound. She has no drug allergies. What is the most appropriate initial treatment?

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Correct answer: CLMWH (enoxaparin) for 5 days then warfarin

DVT in pregnancy requires LMWH (enoxaparin weight-based dosing). DOACs are contraindicated in pregnancy (cross the placenta). Warfarin is also contraindicated in the first and third trimesters (teratogenic, fetal haemorrhage risk). LMWH is continued throughout pregnancy and for at least 6 weeks postpartum (minimum total 3 months treatment).

Reference: eTG Haematology – 2024 – VTE in Pregnancy; RCOG 2024