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Methanol Poisoning — RACP Adult Medicine MCQ

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HardNephrologyMethanol PoisoningRACP Adult Medicine

A 40-year-old man is brought to ED after a deliberate methanol ingestion. ABG: pH 7.18, PaCO₂ 22 mmHg, PaO₂ 98 mmHg, HCO₃⁻ 8 mmol/L. Na⁺ 142, K⁺ 4.2, Cl⁻ 102 mmol/L. Osmolar gap is 25. What is the acid-base disturbance?

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Correct answer: BMetabolic acidosis with respiratory compensation

Metabolic acidosis with respiratory compensation. AG = 142 - (102 + 8) = 32 (high AG). Expected PaCO₂ = 1.5 × 8 + 8 = 20 (actual 22, within 2 mmHg — appropriate). Elevated osmolar gap (>10) with HAGMA suggests toxic alcohol ingestion (methanol or ethylene glycol). Treatment is fomepizole (ADH inhibitor), IV sodium bicarbonate, and urgent haemodialysis.

Reference: Toxicology Handbook (Murray) 3rd Ed 2015; eTG – 2024