Methanol Poisoning — RACP Adult Medicine MCQ
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Correct answer: B — Metabolic acidosis with respiratory compensation
Metabolic acidosis with respiratory compensation. AG = 142 - (102 + 8) = 32 (high AG). Expected PaCO₂ = 1.5 × 8 + 8 = 20 (actual 22, within 2 mmHg — appropriate). Elevated osmolar gap (>10) with HAGMA suggests toxic alcohol ingestion (methanol or ethylene glycol). Treatment is fomepizole (ADH inhibitor), IV sodium bicarbonate, and urgent haemodialysis.
Reference: Toxicology Handbook (Murray) 3rd Ed 2015; eTG – 2024