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Non-Occupational PEP — RACP Adult Medicine MCQ

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ModerateInfectious DiseasesNon-Occupational PEPRACP Adult Medicine

A 30-year-old man presents after unprotected receptive anal intercourse with a partner of unknown HIV status 18 hours ago. His baseline HIV test is negative. He has no significant medical history. What is the most appropriate management?

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Correct answer: C — Triple-agent PEP (tenofovir + emtricitabine + dolutegravir)

Non-occupational high-risk exposure (unprotected receptive anal intercourse) within 72 hours warrants triple PEP (tenofovir/emtricitabine + dolutegravir for 28 days). After completing PEP, if the patient has ongoing risk factors, transition to PrEP should be discussed. STI screening should also be performed.

Reference: ASHM – 2024 – Non-Occupational PEP Guidelines