skip to main content

Multiple Myeloma — RACP Adult Medicine MCQ

Instant feedback + full explanation. One question, done properly.

EasyHaematologyMultiple MyelomaRACP Adult Medicine

A 65-year-old man presents with bone pain, fatigue, and recurrent infections. Investigations show Hb 90 g/L, calcium 3.1 mmol/L, creatinine 210 μmol/L, and total protein 105 g/L with an IgG kappa paraprotein of 48 g/L. Skeletal survey shows multiple lytic lesions. Bone marrow plasma cells are 35%. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — Multiple myeloma

CRAB criteria (Calcium elevation, Renal impairment, Anaemia, Bone lesions) with paraprotein and ≥10% bone marrow plasma cells is diagnostic of multiple myeloma requiring treatment. First-line treatment for transplant-eligible patients is VRd (bortezomib, lenalidomide, dexamethasone) followed by autologous stem cell transplant.

Reference: IMWG – 2024 – Myeloma Diagnostic Criteria; ALLG/MSAG Australian Myeloma Guidelines