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Systemic Sclerosis (Limited) — RACP Adult Medicine MCQ

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ModerateRheumatologySystemic Sclerosis (Limited)RACP Adult Medicine

A 55-year-old woman presents with Raynaud phenomenon, sclerodactyly, oesophageal dysmotility, and digital pitting scars. She has telangiectasiae on her face and hands. Anti-centromere antibody is positive. What is the most likely diagnosis?

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Correct answer: D — Systemic sclerosis

Limited cutaneous systemic sclerosis (formerly CREST) presents with calcinosis, Raynaud phenomenon, esophageal dysmotility, sclerodactyly, and telangiectasiae. Anti-centromere antibody is characteristic. Pulmonary hypertension is the major cause of mortality in limited disease. Annual echocardiographic screening is recommended.

Reference: ACR/EULAR – 2013 – SSc Classification Criteria; BSR 2024 SSc Guidelines