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Toxoplasmosis in Pregnancy — RACP Adult Medicine MCQ

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ModerateInfectious DiseasesToxoplasmosis in PregnancyRACP Adult Medicine

A 40-year-old pregnant woman (28 weeks) presents with fever and cervical lymphadenopathy. She has a cat and reports cleaning the litter tray. CMV IgG is negative. Toxoplasma IgM is positive with low avidity IgG. What is the most likely diagnosis?

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Correct answer: D — Toxoplasmosis

Positive Toxoplasma IgM with low-avidity IgG indicates recent primary infection. Cat litter exposure is a well-known risk factor. In pregnancy, primary toxoplasmosis can cause congenital infection (chorioretinitis, hydrocephalus, intracranial calcifications). Treatment with spiramycin reduces transmission; pyrimethamine-sulfadiazine is used if fetal infection confirmed.

Reference: eTG Antibiotic – 2024 – Toxoplasmosis