skip to main content

EBV Infectious Mononucleosis — RACP Adult Medicine MCQ

Instant feedback + full explanation. One question, done properly.

EasyInfectious DiseasesEBV Infectious MononucleosisRACP Adult Medicine

A 30-year-old man presents with fever (39°C), sore throat, and cervical lymphadenopathy for 10 days. He has hepatosplenomegaly. FBE shows lymphocytosis with >20% atypical lymphocytes. Liver transaminases are mildly elevated. Monospot test is positive. What is the most likely diagnosis?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: C — Epstein-Barr virus infectious mononucleosis

Fever, pharyngitis, lymphadenopathy, hepatosplenomegaly, atypical lymphocytosis, and positive heterophile antibody (Monospot) is diagnostic of EBV infectious mononucleosis. Amoxicillin should be avoided (causes maculopapular rash). Splenic rupture is a rare but serious complication — avoid contact sport for 4–6 weeks.

Reference: eTG Antibiotic – 2024 – EBV Infection