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Type 2 Diabetes with Obesity — RACP Adult Medicine MCQ

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ModerateEndocrinologyType 2 Diabetes with ObesityRACP Adult Medicine

A 60-year-old obese woman (BMI 38 kg/m²) with T2DM (HbA1c 69 mmol/mol) is on metformin 2 g daily and empagliflozin 25 mg. eGFR is 75 mL/min/1.73m². She has had a prior MI. Her priority is weight reduction. What is the most appropriate additional agent?

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Correct answer: EGLP-1 receptor agonist (semaglutide)

GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) promote significant weight loss (5–15%) alongside glycaemic benefit and have proven cardiovascular benefit (SELECT, SUSTAIN-6). In a patient already on metformin and SGLT2i who prioritises weight loss, a GLP-1 RA is the ideal third agent.

Reference: Australian Diabetes Society – 2024 – T2DM Treatment Algorithm