Type 2 Diabetes with Obesity — RACP Adult Medicine MCQ
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Correct answer: E — GLP-1 receptor agonist (semaglutide)
GLP-1 receptor agonists (semaglutide, dulaglutide, liraglutide) promote significant weight loss (5–15%) alongside glycaemic benefit and have proven cardiovascular benefit (SELECT, SUSTAIN-6). In a patient already on metformin and SGLT2i who prioritises weight loss, a GLP-1 RA is the ideal third agent.
Reference: Australian Diabetes Society – 2024 – T2DM Treatment Algorithm