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CIDP — RACP Adult Medicine MCQ

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ModerateNeurologyCIDPRACP Adult Medicine

A 55-year-old man presents with progressive symmetrical weakness over 3 months affecting proximal and distal muscles with areflexia. NCS shows demyelinating features. Symptoms have been present for >8 weeks and continue to progress. CSF protein is elevated. What is the most likely diagnosis?

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Correct answer: D — Chronic inflammatory demyelinating polyneuropathy

CIDP is distinguished from GBS by a progressive or relapsing course beyond 8 weeks. Symmetrical proximal and distal weakness with areflexia and demyelinating NCS features are characteristic. Treatment options include IVIG, plasma exchange, or corticosteroids. Unlike GBS, CIDP requires long-term immunomodulatory therapy.

Reference: eTG Neurology – 2024 – CIDP; EFNS/PNS 2021 CIDP Guidelines