Tranexamic Acid Mechanism — NDEB AFK MCQ
Instant feedback + full explanation. One question, done properly.
Educational content. Not a substitute for clinical judgement or local policy.
Reveal the answer and explanation
Correct answer: C — Inhibition of plasminogen activation, stabilising the fibrin clot and reducing fibrinolysis at the extraction site
Tranexamic acid is an antifibrinolytic agent that competitively inhibits the activation of plasminogen to plasmin, thereby reducing fibrinolysis (breakdown of the fibrin clot). When used as a 5% mouthwash (10 mL swished for 2 minutes, 4 times daily for 2-7 days) after dental extraction in anticoagulated patients, it stabilises the clot locally without affecting systemic coagulation. It is an important adjunctive haemostatic measure in patients on warfarin, DOACs, or antiplatelet agents, reducing post-extraction bleeding significantly.
Reference: SDCEP – Management of Dental Patients Taking Anticoagulants or Antiplatelets, 2022