MMP Autoantibody Targets — NDEB AFK MCQ

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HardOral PathologyMMP Autoantibody TargetsNDEB AFK

Mucocutaneous pemphigoid (mucous membrane pemphigoid) is characterised by autoantibodies directed against which target?

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Correct answer: E — Basement membrane zone components (BP180/BPAg2, laminin-332, type VII collagen, or BP230)

Mucous membrane pemphigoid (MMP, cicatricial pemphigoid) involves autoantibodies directed against various components of the basement membrane zone (BMZ): BP180 (BPAg2/type XVII collagen) is the most common target, followed by laminin-332 (laminin-5), BP230 (BPAg1), and type VII collagen (anchoring fibrils). The autoantibodies disrupt the epithelial-connective tissue attachment, causing subepithelial blistering. In contrast, pemphigus vulgaris involves autoantibodies against desmogleins (intercellular adhesion proteins), causing intraepithelial (suprabasilar) separation. DIF in MMP shows linear IgG/C3 at the BMZ.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016