Anaphylaxis Epinephrine Dose Route — NDEB AFK MCQ
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Correct answer: E — Epinephrine 0.3-0.5 mg IM (1:1,000 concentration) into the mid-outer thigh
Epinephrine (adrenaline) 0.3-0.5 mg IM (1:1,000 concentration, i.e., 1 mg/mL) injected into the mid-outer thigh (vastus lateralis) is the first-line treatment for anaphylaxis in adults. It should be administered immediately upon recognition and may be repeated every 5-15 minutes if symptoms persist. The IM route (not IV — IV epinephrine at 1:1,000 concentration can cause fatal arrhythmia) provides rapid absorption. An EpiPen delivers a pre-measured 0.3 mg dose. Antihistamines and corticosteroids are adjunctive but never replace epinephrine as first-line therapy.
Reference: CDA – Medical Emergencies in the Dental Office; AHA/ACAAI – Anaphylaxis Guidelines