Burning Mouth Nutritional Workup — NDEB AFK MCQ
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Correct answer: D — Iron, vitamin B12, and folate deficiency
Burning mouth symptoms with clinically normal mucosa should prompt investigation for secondary causes before diagnosing primary burning mouth syndrome (BMS). Key nutritional deficiencies to exclude include: iron (associated with angular cheilitis, atrophic glossitis, Plummer-Vinson syndrome), vitamin B12 (atrophic glossitis, paraesthesia, macrocytic anaemia), and folate (glossitis, macrocytic anaemia). A complete blood count with indices, serum ferritin, vitamin B12, and red cell folate should be ordered. Other secondary causes to exclude include diabetes, thyroid disease, candidiasis, and xerostomia.
Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016