Dantrolene Mechanism — NDEB AFK MCQ
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Correct answer: B — Direct-acting skeletal muscle relaxant that inhibits calcium release from the sarcoplasmic reticulum — specific treatment for malignant hyperthermia
Dantrolene sodium is the specific treatment for malignant hyperthermia (MH) — a pharmacogenetic condition triggered by volatile anaesthetic agents and succinylcholine. Dantrolene acts directly on skeletal muscle by binding to the ryanodine receptor (RYR1) on the sarcoplasmic reticulum, inhibiting the uncontrolled release of calcium that drives the hypermetabolic crisis. Dose: 2.5 mg/kg IV, repeated as needed (may require up to 10 mg/kg). It is NOT relevant to dental local anaesthesia (amide LAs do not trigger MH) but is essential knowledge for dental professionals who provide or supervise general anaesthesia.
Reference: Malamed – Medical Emergencies in the Dental Office, 8th ed., 2022