Carbamazepine Oral Side Effects — NDEB AFK MCQ

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ModeratePharmacologyCarbamazepine Oral Side EffectsNDEB AFK

A patient with known epilepsy controlled on carbamazepine presents for dental treatment. Which oral side effect of carbamazepine should the dentist monitor?

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Correct answer: C — Gingival overgrowth

Carbamazepine can cause gingival overgrowth (gingival hyperplasia), similar to phenytoin and other anticonvulsants, although less frequently. Other oral side effects include xerostomia, stomatitis, and glossitis. Carbamazepine also induces hepatic CYP3A4 enzymes, potentially reducing the effectiveness of drugs metabolised by this pathway (e.g., oral contraceptives, benzodiazepines, corticosteroids). Drug interactions should be considered when prescribing concurrent medications.

Reference: Katzung – Basic and Clinical Pharmacology, 15th ed., 2021