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Langerhans Cells — NDEB AFK MCQ

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ModerateBiomedical SciencesLangerhans CellsNDEB AFK

Which of the following cells in the oral epithelium functions as an antigen-presenting cell and is a component of the innate immune surveillance system?

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Correct answer: E — Langerhans cell

Langerhans cells are dendritic antigen-presenting cells (APCs) of the oral epithelium, derived from bone marrow monocyte precursors. They capture, process, and present antigens to T lymphocytes via MHC class II molecules, initiating adaptive immune responses. They are part of the mucosal immune surveillance system and are most abundant in the epithelium of the gingival sulcus and floor of the mouth. Their density is reduced in oral leukoplakia and increased in contact hypersensitivity reactions.

Reference: Nanci – Ten Cate's Oral Histology, 9th ed., 2017