Lateral Periodontal Cyst — NDEB AFK MCQ

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HardOral PathologyLateral Periodontal CystNDEB AFK

A periapical radiograph shows a well-defined radiolucency between the roots of vital maxillary lateral incisor and canine. No associated caries or restoration is present. What is the most likely diagnosis?

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Correct answer: E — Lateral periodontal cyst

A well-defined radiolucency between the roots of vital teeth in the premolar region or between the lateral incisor and canine suggests a lateral periodontal cyst or, historically, a 'globulomaxillary cyst.' The globulomaxillary cyst concept (fissural cyst between premaxilla and maxilla) has been largely abandoned — most lesions in this location are either lateral periodontal cysts, odontogenic keratocysts, or central giant cell granulomas. The key feature is tooth vitality, excluding endodontic pathology.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016