Biopsy Gold Standard — NDEB AFK MCQ
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Correct answer: B — Incisional or excisional biopsy with histopathological examination
Incisional or excisional biopsy with histopathological examination remains the gold standard for definitive diagnosis of oral mucosal lesions. Adjunctive techniques (toluidine blue staining, brush biopsy, autofluorescence) may assist in identifying suspicious areas and guiding biopsy site selection but cannot replace histopathological examination. Incisional biopsy (partial sampling) is used for large or suspected malignant lesions; excisional biopsy (complete removal) is used for small (≤1 cm) benign-appearing lesions.
Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016