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Central Giant Cell Granuloma — NDEB AFK MCQ

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ModerateOral PathologyCentral Giant Cell GranulomaNDEB AFK

Which of the following is a characteristic feature of a central giant cell granuloma of the jaws?

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Correct answer: E — Multinucleated giant cells in a vascular stroma with haemosiderin deposits — histologically identical to brown tumour of hyperparathyroidism

Central giant cell granuloma (CGCG) is a benign intraosseous jaw lesion composed of multinucleated osteoclast-like giant cells in a cellular vascular stroma with haemosiderin deposits and reactive new bone formation. It is histologically identical to the brown tumour of hyperparathyroidism — serum calcium and PTH levels must be checked to exclude hyperparathyroidism. CGCG is more common in the anterior mandible, in patients under 30, and in females. Aggressive variants may require corticosteroid injection or calcitonin therapy.

Reference: Neville – Oral and Maxillofacial Pathology, 4th ed., 2016