skip to main content

AERD NSAID Contraindication — NDEB AFK MCQ

Instant feedback + full explanation. One question, done properly.

HardPharmacologyAERD NSAID ContraindicationNDEB AFK

Which of the following drugs should be avoided in patients with a history of aspirin-exacerbated respiratory disease (AERD/Samter triad)?

Educational content. Not a substitute for clinical judgement or local policy.

Reveal the answer and explanation

Correct answer: E — All NSAIDs (ibuprofen, naproxen, ketorolac)

Aspirin-exacerbated respiratory disease (AERD, Samter triad: asthma, nasal polyposis, aspirin sensitivity) is a condition where COX-1 inhibition by aspirin or other NSAIDs triggers bronchospasm and potentially anaphylactoid reactions. ALL traditional NSAIDs (ibuprofen, naproxen, ketorolac) are contraindicated. Acetaminophen at doses ≤1000 mg is generally safe. Selective COX-2 inhibitors (celecoxib) may be tolerated but should be used with caution and medical clearance. The reaction is pseudoallergic (non-IgE-mediated).

Reference: Katzung – Basic and Clinical Pharmacology, 15th ed., 2021