Type III Hypersensitivity — NDEB AFK MCQ

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ModerateBiomedical SciencesType III HypersensitivityNDEB AFK

A Type III hypersensitivity reaction (immune complex-mediated) is involved in the pathogenesis of which condition?

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Correct answer: B — Rheumatoid arthritis

Type III hypersensitivity involves the formation and deposition of antigen-antibody (immune) complexes in blood vessel walls and tissues, activating complement and recruiting neutrophils, causing tissue damage. Rheumatoid arthritis, systemic lupus erythematosus, serum sickness, and post-streptococcal glomerulonephritis are examples. Type I is immediate (IgE-mediated: anaphylaxis). Type II is antibody-mediated cytotoxicity (haemolytic disease). Type IV is delayed/cell-mediated (contact dermatitis, graft rejection).

Reference: Abbas – Cellular and Molecular Immunology, 10th ed., 2021