Amoxicillin-Clavulanate Indication — NDEB AFK MCQ
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Correct answer: E — Dental infection unresponsive to amoxicillin alone or involving beta-lactamase-producing organisms
Amoxicillin-clavulanate combines amoxicillin with clavulanic acid, a beta-lactamase inhibitor that extends the spectrum to include beta-lactamase-producing organisms (certain Prevotella, Staphylococcus). It is indicated when a dental infection fails to respond to amoxicillin alone (suggesting resistant organisms) or when infection involves beta-lactamase producers. It is not used for routine uncomplicated dental infections or IE prophylaxis (amoxicillin alone is sufficient for prophylaxis).
Reference: CDA – Antibiotic Prescribing for Dental Practitioners, 2019